NEPG is proud of being the first Vitamin C producer in China, as well as the inventor of the two steps fermentation technology of VC production;
products capacity is the biggest one in the world; NEPG is the leading Fosfomycin producer in China.
They were treated in the following way; G-I = 10 ml/kg/p.o, normal saline, G-II = 10 ml/kg/p.o, 5% CMC, G-III and IV = 200 mg/kg/p.o,
, G-V to VII = aqP.a in doses 200, 400 and 800 mg/kg/p.o, respectively and G-VIII to G-X = nhP.a doses 200, 400 and 800 mg/kg/p.o, respectively, for seven days consecutively.
Group I treated as vehicle control (normal saline), Group II was treated with standard – (
400 mg/kg/i.p.) and Groups III and IV were administered two different doses of EASL 50, 250 mg/kg/per orally, Group V is treated with scopolamine (0.4 mg/kg p.o)., respectively, which were administered up to 7 days.
Valproic acid (VPA) is typically the first pharmacological treatment for myoclonic seizures; however, its mitochondrial toxicity provides limitations for use in the treatment of mitochondrial disorders., Other commonly used agents include levetiracetam (LEV), clonazepam (CZP), zonisamide (ZNS), topiramate (TPM) and a high dose of
., Recent evidence has supported the use of LEV as the first line of treatment for myoclonic seizures; however, the treatment effects have been unsatisfactory and inconsistent.,, Therefore, additional clinical trials must be conducted to find more suitable treatments for myoclonic seizures in MERRF.
She used betahistine, corticosteroids (oral and intratympanically),
, trimetazidine, ginkgo biloba, and cinnarizine.
: a review of pharmacological properties and clinical uses.
Double-blind, placebo-controlled trial on the effect of
on breath-holding spells.
[23,24] Recently, evidence for safe and effective use of
, especially in hyperactive children to control Breath holding spells has emerged, but it still lacks FDA approval.
LEV is a pyrrolidone derivative that has been developed from
. It is presumed to act on presynaptic neurotransmitter release by binding to synaptic vesicle protein 2A (SV2A), a glycoprotein that is part of the membrane of presynaptic neurotransmitter-containing vesicles in neurons and neuroendocrine cells.
Rosa et al., “
prevents scopolamine-induced memory impairment and decrease of NTPDase, 5′-nucleotidase and adenosine deaminase activities,” Neurochemical Research, vol.
The effect of
on Danio rerio with ethanol-induced memory impairment.
The first nootropic drug put on the market was